What is Cell Painting

Cell Painting (CP) is a high-content, image-based morphological profiling assay. For the assay, up to six fluorescent dyes are used, revealing eight cellular components or organelles. Combined with sophisticated image analysis tools, this approach allows the user to obtain detailed cellular profiles, consisting of hundreds or even thousands of morphological features: measures of intensity, size, shape, etcetera. The amount of detail in these morphological profiles makes this assay sensitive to subtle cellular changes, and therefore a valuable tool to assess cellular responses to drugs or genetic perturbations. 

Further Reading

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